EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | schisandrol A | isolated from fruit of Schisandra chinensis. Increases cellular retention of P-glycoprotein substrates such as rhodamine 123. Schisandrol A stimulates basal P-glycoprotein ATPase activity, is not competitive to verapamil or progesterone and decreases their Km value without changing Vmax values | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
7.6.2.2 | 0.00198 | - |
verapamil/in | presence of 0.4 mM schisandrol A, pH 7.4, 37°C | Homo sapiens | |
7.6.2.2 | 0.00377 | - |
progesterone/in | presence of 0.4 mM schisandrol A, pH 7.4, 37°C | Homo sapiens | |
7.6.2.2 | 0.00397 | - |
verapamil/in | presence of 0.04 mM schisandrol A, pH 7.4, 37°C | Homo sapiens | |
7.6.2.2 | 0.0048 | - |
progesterone/in | presence of 0.04 mM schisandrol A, pH 7.4, 37°C | Homo sapiens | |
7.6.2.2 | 0.00579 | - |
verapamil/in | pH 7.4, 37°C | Homo sapiens | |
7.6.2.2 | 0.0207 | - |
progesterone/in | pH 7.4, 37°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + progesterone/in | - |
Homo sapiens | ADP + phosphate + progesterone/out | - |
? | |
7.6.2.2 | ATP + H2O + verapamil/in | - |
Homo sapiens | ADP + phosphate + verapamil/out | - |
? |