Literature summary extracted from

Munoz-Bertomeu, J.; Sales, E.; Ros, R.; Arrillaga, I.; Segura, J.
Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia (2007), Plant Biotechnol. J., 5, 746-758.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.1.1.34	additional information	transgenic expression of the N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase from Arabidopsis thaliana in Lavandula latifolia plants enhances production of essential oils and sterols in the different lines of transgenic plants, expression of HMGR1S also increases the amount of the end-product sterols beta-sitosterol and stigmasterol by 1.8fold and 1.9fold, respectively, but does not affect the accumulation of carotenoids or chlorophylls, overview	Arabidopsis thaliana

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.34	membrane	-	Arabidopsis thaliana	16020	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.34	hydroxymethylglutaryl-CoA + NADPH + H+	Arabidopsis thaliana	key enzyme of the mevalonic acid pathway catalysing the first committed step with NADPH as cofactor, overview	mevalonate + NADP+ + CoA	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.34	Arabidopsis thaliana	-	gene HMG1	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.34	leaf	-	Arabidopsis thaliana	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.34	hydroxymethylglutaryl-CoA + NADPH + H+	-	Arabidopsis thaliana	mevalonate + NADP+ + CoA	-	?
1.1.1.34	hydroxymethylglutaryl-CoA + NADPH + H+	key enzyme of the mevalonic acid pathway catalysing the first committed step with NADPH as cofactor, overview	Arabidopsis thaliana	mevalonate + NADP+ + CoA	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.34	3-hydroxy-3-methylglutaryl CoA reductase	-	Arabidopsis thaliana
1.1.1.34	HMGR1S	-	Arabidopsis thaliana

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.34	NADPH	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)