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Literature summary extracted from

  • Stec, D.E.; Roman, R.J.; Flasch, A.; Rieder, M.J.
    Functional polymorphism in human CYP4F2 decreases 20-HETE production (2007), Physiol. Genomics, 30, 74-81.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.94 wild-type and mutant DNA and amino acid sequence determinations, functional nonsynonymous polymorphisms, overview, expression of wild-type and mutant genes in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.94 V433M the functional polymorphism in human Cyp4F2 decreases 20-hydroxyeicosatetraenoic acid production, but does not influence the omega-hydroxylation of leukotriene B4, screening and genotyping of African and European Americans, overview Homo sapiens
1.14.14.94 W12G the mutant enzyme activity is similar to the wild-type enzyme, screening and genotyping of African and European Americans, overview Homo sapiens
1.14.14.94 W12G/V433M the functional polymorphism in human Cyp4F2 decreases 20-hydroxyeicosatetraenoic acid production, but does not influence the omega-hydroxylation of leukotriene B4, screening and genotyping of African and European Americans, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.14.94 Fe2+ a cytochrome P450 enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.94 leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.94 additional information Homo sapiens cytochrome P450 4F2 gene encodes for the major CYP enzyme responsible for the synthesis of 20-hydroxyeicosatetraenoic acid in the human kidney ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.94 Homo sapiens P78329
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.94 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.94 arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens ?
-
 ?
1.14.14.94 leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.94 additional information cytochrome P450 4F2 gene encodes for the major CYP enzyme responsible for the synthesis of 20-hydroxyeicosatetraenoic acid in the human kidney Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.94 CYP4F2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.94 cytochrome P450
-
 Homo sapiens