EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.14 | GRK1 peptides | bovine commercial preparation, inhibition analysis of enzyme binding to S-modulin, overview | Lithobates catesbeianus | |
2.7.11.14 | S-modulin/recoverin | recombinant myristoylated S-modulin overexpressed in Escherichia coli, GRK1 activity is inhibited by binding of the Ca2+-bound form of S-modulin/recoverin, determination of the binding site by peptide mapping, binding involves Leu6, Asn12, and Tyr15, mutation of these residues reduces the inhibition significantly, inhibition mechanism, overview | Lithobates catesbeianus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.14 | membrane | - |
Lithobates catesbeianus | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.14 | Ca2+ | GRK1 activity is inhibited by binding of the Ca2+-bound form of S-modulin/recoverin | Lithobates catesbeianus | |
2.7.11.14 | Mg2+ | - |
Lithobates catesbeianus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.14 | ATP + rhodopsin | Lithobates catesbeianus | GRK1 is a visual pigment kinase in rods and is essential for inactivation of light-activated rhodopsin | ADP + phosphorhodopsin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.14 | Lithobates catesbeianus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.14 | retinal rod | - |
Lithobates catesbeianus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.14 | ATP + rhodopsin | - |
Lithobates catesbeianus | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | GRK1 is a visual pigment kinase in rods and is essential for inactivation of light-activated rhodopsin | Lithobates catesbeianus | ADP + phosphorhodopsin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.14 | GRK1 | - |
Lithobates catesbeianus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.11.14 | 22 | - |
assay at room temperature | Lithobates catesbeianus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.11.14 | 7.5 | - |
assay at | Lithobates catesbeianus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.14 | ATP | - |
Lithobates catesbeianus |