Literature summary extracted from

Gilardi, F.; Mitro, N.; Godio, C.; Scotti, E.; Caruso, D.; Crestani, M.; De Fabiani, E.
The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol (2007), Pharmacol. Ther., 116, 449-472.

Application

EC Number	Application	Comment	Organism
1.14.14.23	medicine	polymorphisms/mutations described so far at the CYP7A1 promoter do not impair enzyme activity and most likely do not contribute directly to hypercholesterolemia and/or increased cardiovascular risk	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.23	Homo sapiens	-	-	-
1.14.14.23	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.14.23	Hep-G2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.23	cholesterol + [reduced NADPH-hemoprotein reductase] + O2	-	Mus musculus	7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
1.14.14.23	cholesterol + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.23	cholesterol 7alpha-hydroxylase	-	Mus musculus
1.14.14.23	cholesterol 7alpha-hydroxylase	-	Homo sapiens
1.14.14.23	CYP7A1	-	Mus musculus
1.14.14.23	CYP7A1	-	Homo sapiens

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Release 2023.1 (January 2023)