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Literature summary extracted from

  • Chrzanowska, M.; Kurzawski, M.; Dro?dzik, M.; Mazik, M.; Oko, A.; Czekalski, S.
    Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients (2006), Pharmacol. Rep., 58, 973-978.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine patients carrying a variant genotype have low TPMT activity and produce elevated levels of 6-thioguanine nucleotides in their red blood cells, 6-TGN accumulation may result in azathioprine-induced bone marrow myelosuppression in the course of treatment with the drug in a standard dosage regimen in patients following renal transplantation Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.67 A154T variant TPMT*3B Homo sapiens
2.1.1.67 A80P variant TPMT*2 Homo sapiens
2.1.1.67 Y240C variant TPMT*3C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.67 cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 blood
-
Homo sapiens
-
2.1.1.67 erythrocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.67 additional information
-
activity of TPMT in nmol of the formed 6-mMP/g Hb/h, dialyzed patients, total 30.6, females 30.1, males 31.7, control group, total 28.4, females 28.4, males 28.7 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?
2.1.1.67 S-adenosyl-L-methionine + azathioprine
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine S-methyltransferase
-
Homo sapiens
2.1.1.67 TPMT
-
Homo sapiens