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Literature summary extracted from

  • Zhang, X.; Diasio, R.B.
    Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy (2007), Pharmacogenomics, 8, 257-265.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.1 phorbol-12-myristate activates gene expression Homo sapiens
1.3.1.1 specificity protein 1 transcription activator Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.1 110000
-
 2 * 110000, SDS-PAGE Homo sapiens
1.3.1.1 220000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.1 breast cancer cell
-
 Homo sapiens
-
1.3.1.1 colorectal cancer cell
-
 Homo sapiens
-
1.3.1.1 gastric cancer cell
-
 Homo sapiens
-
1.3.1.1 lung cancer cell
-
 Homo sapiens
-
1.3.1.1 ovary cancer cell
-
 Homo sapiens
-
1.3.1.1 pancreatic cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.1 5-fluorouracil + NADH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NAD+
-
 ?
1.3.1.1 uracil + NADH + H+
-
 Homo sapiens 5,6-dihydrouracil + NAD+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.1.1 homodimer 2 * 110000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.3.1.1 dihydropyrimidine dehydrogenase
-
 Homo sapiens
1.3.1.1 DPD
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.1 NAD+
-
 Homo sapiens