Literature summary extracted from

Celtikci, B.; Leclerc, D.; Lawrance, A.K.; Deng, L.; Friedman, H.C.; Krupenko, N.I.; Krupenko, S.A.; Melnyk, S.; James, S.J.; Peterson, A.C.; Rozen, R.
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice (2008), Pharmacogenet. Genomics, 18, 577-589.

Application

EC Number	Application	Comment	Organism
1.5.1.20	medicine	MTHFR deficiency in mice is accompanied with hyperhomocysteinemia and decreased hematocrit, hemoglobin, and red blood cell numbers, increased nephrotoxicity und hepatotoxicity compared to wild type animals	Mus musculus

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.5.1.20	expressed in Mus musculus	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.5.1.20	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.5.1.20	blood	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.5.1.20	5,10-methylenetetrahydrofolate + reduced acceptor	-	Mus musculus	5-methyltetrahydrofolate + oxidized acceptor	-	ir

Synonyms

EC Number	Synonyms	Comment	Organism
1.5.1.20	methylenetetrahydrofolate reductase	-	Mus musculus
1.5.1.20	MTHFR	-	Mus musculus

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Release 2023.1 (January 2023)