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Literature summary extracted from

  • Fakis, G.; Boukouvala, S.; Kawamura, A.; Kennedy, S.
    Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis (2007), Pharmacogenet. Genomics, 17, 181-188.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.5 medicine a polymorphic homologue of human NAT2 is characterized in the rhesus macaque, to facilitate investigations of the postulated involvement of this isoenzyme in the toxicogenetics of endometriosis Macaca mulatta
2.3.1.5 medicine to better understand the possible relationship between the NAT2 gene and endometriosis, its homologue in the resus macaque is characterized Macaca mulatta

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 expressed in CHO cells Macaca mulatta
2.3.1.5 expressed in Escherichia coli and in CHO cells Macaca mulatta
2.3.1.5 for expression in mammalian cells Macaca mulatta

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.5 C624T synonymous polymorphism Macaca mulatta
2.3.1.5 G691A nonsynonymous polymorphism, causing a V231I substitution Macaca mulatta
2.3.1.5 recombinant (MACMU)NAT2 protein analysed for the ability to acetylate NAT substrates and bind anti-NAT antibodies Macaca mulatta
2.3.1.5 V231I polymorphic allele Nat2*2 found in rhesus macaque, differentiated by one nonsynonymous G691A polymorphism, resulting in a Val231Ile substitution. Mutant shows differences in activity with most substrates (pmol/min/luminescence unit): 183 (p-anisidine), 4 (procainamide), 3 (sulphamethazine), 11 (5-aminosalicylate), 3 (p-aminobenzoic acid) Macaca mulatta

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Macaca mulatta
-
-
-
2.3.1.5 Macaca mulatta Q7YRG5 polymorphic allele Nat2*1
-
2.3.1.5 Macaca mulatta Q7YRG5 polymorphic allele Nat2*2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 blood
-
Macaca mulatta
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.5 additional information
-
specific activities of various substrates (pmol/min/luminescence unit): 183 (p-anisidine), 4 (procainamide), 3 (sulphamethazine), 11 (5-aminosalicylate), 3 (p-aminobenzoic acid) Macaca mulatta
2.3.1.5 additional information
-
specific activities of various substrates (pmol/min/luminescence unit): 197 (p-anisidine), 18 (procainamide), 12 (sulphamethazine), 2 (5-aminosalicylate), 0 (p-aminobenzoic acid) Macaca mulatta

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
Macaca mulatta CoA + N-acetyl-4-aminobenzoic acid
-
?
2.3.1.5 acetyl-CoA + 5-aminosalicylate
-
Macaca mulatta CoA + 5-acetylamino-2-hydroxybenzoate
-
?
2.3.1.5 acetyl-CoA + 5-aminosalicylate
-
Macaca mulatta CoA + N-acetyl-5-aminosalicylate
-
?
2.3.1.5 acetyl-CoA + 5-aminosalicylate
-
Macaca mulatta ?
-
?
2.3.1.5 acetyl-CoA + p-aminobenzoic acid poor activity Macaca mulatta CoA + N-acetyl-p-aminobenzoic acid
-
?
2.3.1.5 acetyl-CoA + p-aminobenzoic acid
-
Macaca mulatta ?
-
?
2.3.1.5 acetyl-CoA + p-anisidine
-
Macaca mulatta ?
-
?
2.3.1.5 acetyl-CoA + p-anisidine
-
Macaca mulatta CoA + p-methoxyacetanilide
-
?
2.3.1.5 acetyl-CoA + p-anisidine
-
Macaca mulatta CoA + N-acetylanisidine
-
?
2.3.1.5 acetyl-CoA + procainamide
-
Macaca mulatta CoA + N-acetylprocainamide
-
?
2.3.1.5 acetyl-CoA + procainamide
-
Macaca mulatta ?
-
?
2.3.1.5 acetyl-CoA + procainamide lower activity Macaca mulatta CoA + N-acetyl-2-procainamide
-
?
2.3.1.5 acetyl-CoA + sulfamethazine
-
Macaca mulatta ?
-
?
2.3.1.5 acetyl-CoA + sulphamethazine
-
Macaca mulatta CoA + N-acetylsulphamethazine
-
?
2.3.1.5 sulphamethazine + acetyl-CoA
-
Macaca mulatta N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 arylamine N-acetyltransferase
-
Macaca mulatta
2.3.1.5 arylamine N-acetyltransferase 2
-
Macaca mulatta
2.3.1.5 NAT2
-
Macaca mulatta
2.3.1.5 NAT2*1 polymorphic allele Nat2*1, differentiated by one synonymous C624T polymorphism Macaca mulatta
2.3.1.5 NAT2*2 polymorphic allele Nat2*2, differentiated by one nonsynonymous G691A polymorphism, resulting in a Val231Ile substitution Macaca mulatta
2.3.1.5 rhesus NAT2
-
Macaca mulatta

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.5 37
-
assay at Macaca mulatta

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.5 7.4
-
assay at Macaca mulatta