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Literature summary extracted from

  • Jelski, W.; Chrostek, L.; Szmitkowski, M.
    The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer (2007), Pancreas, 35, 142-146.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Homo sapiens
-
-
-
1.1.1.284 Homo sapiens
-
-
-
1.2.1.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.1 pancreas total activity of alcohol dehydrogenase is not significantly different in cancer and normal cells. The differences between enzymes of drinkers and nondrinkers in both cancer and healthy tissue are not significant Homo sapiens
-
1.1.1.284 pancreas from healthy individuals, cancer patients, including drinkers and nondrinkers Homo sapiens
-
1.2.1.3 pancreas
-
 Homo sapiens
-
1.2.1.3 pancreatic cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.284 additional information
-
 enzyme activities in pancreas from healthy individuals, cancer patients, including drinkers and nondrinkers, overview Homo sapiens
1.1.1.284 0.00089
-
 activity in pancreas from healthy persons, drinkers and nondrinkers Homo sapiens
1.1.1.284 0.0012
-
 activity in pancreas from cancer patients, drinkers and nondrinkers Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.284 n-octanol + NAD+
-
 Homo sapiens n-octanal + NADH
-
 ?
1.2.1.3 6-methoxy-2-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 6-methoxy-2-naphthoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.284 ADH III
-
 Homo sapiens
1.1.1.284 class III ADH
-
 Homo sapiens
1.1.1.284 class III alcohol dehydrogenase
-
 Homo sapiens
1.2.1.3 ALDH
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.284 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.284 9.6
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.284 NAD+
-
 Homo sapiens
1.2.1.3 NAD+
-
 Homo sapiens