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Literature summary extracted from

  • Andrian, E.; Grenier, D.; Rouabhia, M.
    Porphyromonas gingivalis gingipains mediate the shedding of syndecan-1 from the surface of gingival epithelial cells (2006), Oral Microbiol. Immunol., 21, 123-128.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.37 additional information Porphyromonas gingivalis important virulence factors in periodontitis, involved in the perturbation of host defense and the destruction and invasion of host tissues, degradation of host’s proteins such as ICAM-1m VCAM-1, catenins, and cadherins, involved in the shedding of syndecan-1 ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.37 Porphyromonas gingivalis
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 ATCC33277 and different gingipain deficient mutants
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.37 benzoyl-L-arginine-4-nitroanilide + H2O
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 Porphyromonas gingivalis benzoyl-L-arginine + 4-nitroaniline
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 ?
3.4.22.37 additional information important virulence factors in periodontitis, involved in the perturbation of host defense and the destruction and invasion of host tissues, degradation of host’s proteins such as ICAM-1m VCAM-1, catenins, and cadherins, involved in the shedding of syndecan-1 Porphyromonas gingivalis ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.37 Arg-gingipain cysteine proteinases, products of the genes rgpA and rgpB Porphyromonas gingivalis