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Literature summary extracted from

  • Slanar, O.; Bortlik, M.; Buzkova, H.; Donoval, R.; Pechandova, K.; Sebesta, I.; Lukas, M.; Perlik, F.
    Polymorphisms of the TPMT gene in the Czech healthy population and patients with inflammatory bowel disease (2008), Nucleosides Nucleotides Nucleic Acids, 27, 835-838.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine genetic variation in thiopurine S-methyltransferase is a major factor for wide variation in the metabolism and safety of thiopurine drugs Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.67 additional information more than 20 variant alleles leading to deficient methylation phenotype have been described, four of them, TPMT*2, TPMT*3A, TPMT*3B and TPMT*3C, account for 80-95% of low activity alleles in various populations Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.67 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 peripheral blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine inactivation Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine nucleoside inactivation Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine nucleoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine S-methyltransferase
-
 Homo sapiens
2.1.1.67 TMPT
-
 Homo sapiens