EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.6.3.1 | aminoethylbenzenesulfonylfluoride | treatment blocks the induction of reactive oxygen species production by the dopaminergic toxin MPP+. Co-treatment with inhibitors aminoethylbenzenesulfonylfluoride, apocynin, or diphenylene iodinium significantly suppresses MPP*-induced cell death and attenuates MPP*-induced increases in caspase-3 enzymatic activity | Rattus norvegicus | |
1.6.3.1 | apocynin | treatment blocks the induction of reactive oxygen species production by the dopaminergic toxin MPP+. Co-treatment with inhibitors aminoethylbenzenesulfonylfluoride, apocynin, or diphenylene iodinium significantly suppresses MPP*-induced cell death and attenuates MPP*-induced increases in caspase-3 enzymatic activity | Rattus norvegicus | |
1.6.3.1 | diphenylene iodonium | treatment blocks the induction of reactive oxygen species production by the dopaminergic toxin MPP+. Co-treatment with inhibitors aminoethylbenzenesulfonylfluoride, apocynin, or diphenylene iodinium significantly suppresses MPP*-induced cell death and attenuates MPP*-induced increases in caspase-3 enzymatic activity | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.3.1 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.3.1 | N-27 cell | mesencephalic dopaminergic neuronal cells. Cells express key NAD(P)H oxidase subunits gp91phox and p67phox, and NAD(P)H oxidase are a key determinant of toxin MPP*-mediated dopaminergic degeneration | Rattus norvegicus | - |