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Literature summary extracted from

  • Nagasawa, K.; Kakuda, T.; Higashi, Y.; Fujimoto, S.
    Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons (2007), Neurosci. Lett., 429, 120-125.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 AA861 a 12-LOX inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.31 arachidonate + O2 Rattus norvegicus poly(ADP-ribose) polymerase activation of 12-LOX, but not NADPH oxidase, following zinc release, might play an important role in reactive oxygen species generation and decrease of viability in glucose-reload-treated neurons, overview (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
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Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Rattus norvegicus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 neuron primary cortical culture Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2
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 Rattus norvegicus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2 poly(ADP-ribose) polymerase activation of 12-LOX, but not NADPH oxidase, following zinc release, might play an important role in reactive oxygen species generation and decrease of viability in glucose-reload-treated neurons, overview Rattus norvegicus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12-lipoxygenase
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 Rattus norvegicus
1.13.11.31 12-LOX
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 Rattus norvegicus