Literature summary extracted from

Kocakova, I.; Svoboda, M.; Kubosova, K.; Chrenko, V.; Roubalova, E.; Krejci, E.; Sefr, R.; Slampa, P.; Frgala, T.; Zaloudik, J.
Preoperative radiotherapy and concomitant capecitabine treatment induce thymidylate synthase and thymidine phosphorylase mRNAs in rectal carcinoma (2007), Neoplasma, 54, 447-453.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.4.2.4	additional information	preoperative radiotherapy (cumulative dose of 45 Gy) and concomitant capecitabine (825 mg/m2) treatment induce 2.3fold increase of thymidine phosphorylase mRNA levels	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.2.4	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.2.4	rectal adenocarcinoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.2.4	thymidine + phosphate	-	Homo sapiens	thymine + 2-deoxy-D-ribose 1-phosphate	-	?

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Release 2023.1 (January 2023)