Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Streck, E.L.; Rezin, G.T.; Barbosa, L.M.; Assis, L.C.; Grandi, E.; Quevedo, J.
    Effect of antipsychotics on succinate dehydrogenase and cytochrome oxidase activities in rat brain (2007), Naunyn Schmiedebergs Arch. Pharmacol., 376, 127-133.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.5.1 aripiprazole chronic administration of the antipsychotic agent, increases SDH activity in the prefrontal cortex at high doses of 20 mg/kg body weight Rattus norvegicus
7.1.1.9 additional information haloperidol, clozapine, olanzapine, or aripiprazole do not alter COX Rattus norvegicus

Application

EC Number Application Comment Organism
7.1.1.9 medicine antipsychotic drugs do not alter COX Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.1 clozapine chronic administration of the antipsychotic agent, inhibit SDH activity only in the striatum Rattus norvegicus
1.3.5.1 haloperidol chronic administration of the antipsychotic agent, inhibits SDH activity in the hippocampus and striatum but not in the cerebellum, cortex, and prefrontal cortex Rattus norvegicus
1.3.5.1 olanzapine chronic administration of the antipsychotic agent, inhibits SDH activity only in the cerebellum, but not in the hippocampus, striatum, cortex, and prefrontal cortex Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 mitochondrion
-
 Rattus norvegicus 5739
-
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Rattus norvegicus
-
 male Wistar rats
-
7.1.1.9 Rattus norvegicus
-
 adult male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.5.1 brain
-
 Rattus norvegicus
-
7.1.1.9 brain
-
 Rattus norvegicus
-
7.1.1.9 cerebellum
-
 Rattus norvegicus
-
7.1.1.9 hippocampus
-
 Rattus norvegicus
-
7.1.1.9 additional information striatum and cortex Rattus norvegicus
-
7.1.1.9 prefrontal cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 succinate + oxidized 2,6-dichlorophenolindophenol in presence of phenazine methosulfate Rattus norvegicus fumarate + reduced 2,6-dichlorophenolindophenol
-
 ?
1.3.5.1 succinate + oxidized 2,6-dichlorophenolindophenol in presence of phenazine methosulfate Rattus norvegicus fumarate + reduced 2,6-dichloroindophenol
-
 ?
7.1.1.9 reduced cytochrome c + O2 + H+
-
 Rattus norvegicus oxidized cytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.5.1 More cf. EC 1.3.5.1 Rattus norvegicus
1.3.5.1 More cf. EC 1.3.99.1 Rattus norvegicus
1.3.5.1 SDH
-
 Rattus norvegicus
7.1.1.9 COX
-
 Rattus norvegicus
7.1.1.9 cytochrome oxidase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.5.1 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.5.1 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.1 2,6-dichlorophenolindophenol in presence of phenazine methosulfate Rattus norvegicus