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Literature summary extracted from

  • Roll-Mecak, A.; Vale, R.D.
    Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin (2008), Nature, 451, 363-367.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.6.1.1 medicine the analysis provides insights into the structural defects in spastin that arise from mutations identified in hereditary paraplegia patients Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.1
-
 Drosophila melanogaster

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.6.1.1 the X-ray structure of the nucleotide-free, monomeric AAA domain of Drosophila melanogaster spastin, residues 464-758, is solved at a resolution of 2.7 A Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.1 ATP + H2O Drosophila melanogaster
-
 ADP + phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.1 Drosophila melanogaster Q8I0P1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.1
-
 Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.1 ATP + H2O
-
 Drosophila melanogaster ADP + phosphate
-
 ir

Subunits

EC Number Subunits Comment Organism
5.6.1.1 hexamer
-
 Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
5.6.1.1 spastin
-
 Drosophila melanogaster