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Literature summary extracted from

  • Wang, X.; Wang, J.; Gengyo-Ando, K.; Gu, L.; Sun, C.L.; Yang, C.; Shi, Y.; Kobayashi, T.; Shi, Y.; Mitani, S.; Xie, X.S.; Xue, D.
    C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1 (2007), Nat. Cell Biol., 9, 541-549.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.1 WAH-1 a mitochondrial apoptogenic factor, a homologue of the apoptosis-inducing factor, AIF, required for externalization of phosphatidylserine to the cell surface of apoptotic cells. The Wah-1 effect is specific and independent of age, phenotypes of siRNA mutants and overexpressing mutants, overview Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
7.6.2.1 additional information construction of two deletion null mutants of scrm-1, mutants tm698 and tm805, which show more cell corpse than the wild-type embryos and a defect in cell corps engulfment, the average cell corpse duration in mutant scrm-1 tm698 is 55 min, in mutant scrm-1 tm805 57 in, and in wild-type embryos 33 min. The mutants also show highly decreased externalization of phosphatidylserine on the surface of apoptotic germ cells, phenotypes, overview Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.1 plasma membrane
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 Caenorhabditis elegans 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.1 additional information Caenorhabditis elegans the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface of apoptotic germ cells, a conserved event in worms, after activation by WAH-1, a mitochondrially released apoptotic factor, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.1 Caenorhabditis elegans
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.1 embryo
-
 Caenorhabditis elegans
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.1 additional information the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface of apoptotic germ cells, a conserved event in worms, after activation by WAH-1, a mitochondrially released apoptotic factor, overview Caenorhabditis elegans ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.1 phospholipid scramblase
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 Caenorhabditis elegans
7.6.2.1 SCRM-1
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 Caenorhabditis elegans