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Literature summary extracted from

  • Wang, S.; Yan, J.; Hao, D.; Niu, X.; Cheng, M.
    Synthesis and activity of a new series of (Z)-3-phenyl-2-benzoylpropenoic acid derivatives as aldose reductase inhibitors (2007), Molecules, 12, 885-895.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.21 molecular modeling of complex with NADP+ and inhibitor (2Z)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 (2Z)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
-
 Rattus norvegicus
1.1.1.21 (2Z)-3-(3-methoxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
-
 Rattus norvegicus
1.1.1.21 epalrestat
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens P15121
-
-
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH
-
 Rattus norvegicus glycerol + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADP+
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.000075
-
 37°C, pH 7.0 Rattus norvegicus epalrestat
1.1.1.21 0.00049
-
 37°C, pH 7.0 Rattus norvegicus (2Z)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
1.1.1.21 0.00795
-
 37°C, pH 7.0 Rattus norvegicus (2Z)-3-(3-methoxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid