BRENDA - Enzyme Database show

Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma

Sartini, D.; Santarelli, A.; Rossi, V.; Goteri, G.; Rubini, C.; Ciavarella, D.; Lo Muzio, L.; Emanuelli, M.; Mol. Med. 13, 415-421 (2007)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.1.1.1
pharmacology
NNMT as potential biomarker and therapeutic target
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.1
Homo sapiens
P40261
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
oral mucosa
-
Homo sapiens
-
2.1.1.1
oral squamous cell carcinoma cell line
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.1
additional information
-
expression levels of NNMT in oral squamous cell carcinoma (OSCC), quantitative real-time PCR, Western-Blot and immunohistochemical analyses, upregulation in tumor cells, correlation between NNMT upregulation and favorable prognosis of oral squamous cell carcinoma patients
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
NNMT potential as tumor marker
689036
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
2.1.1.1
pharmacology
NNMT as potential biomarker and therapeutic target
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
oral mucosa
-
Homo sapiens
-
2.1.1.1
oral squamous cell carcinoma cell line
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.1
additional information
-
expression levels of NNMT in oral squamous cell carcinoma (OSCC), quantitative real-time PCR, Western-Blot and immunohistochemical analyses, upregulation in tumor cells, correlation between NNMT upregulation and favorable prognosis of oral squamous cell carcinoma patients
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
NNMT potential as tumor marker
689036
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?