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Literature summary extracted from

  • Ning, G.; Ouyang, H.; Wang, S.; Chen, X.; Xu, B.; Yang, J.; Zhang, H.; Zhang, M.; Xia, G.
    3,5-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation (2008), Mol. Endocrinol., 22, 1682-1694.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.154 additional information 3,5-cyclic adenosine monophosphate response element binding protein and follicle stimulating hormone, FSH. Up-regulate the enzyme expression during or before oocyte meturation, respectively. FSH includes via MAPK activation, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 KG-501 the enzyme can be rescued by progesterone Mus musculus
1.14.14.154 RS21607 specific inhibition of CYP51, the enzyme can be rescued by progesterone Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.154 additional information
-
 additional information kinetics, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.154 microsome
-
 Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.14.154 Fe2+ a cytochrome P450 enzyme Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 additional information Mus musculus the enzyme is involved in follicle-stimulating hormone-induced mouse oocyte maturation and follicle-stimulating hormone-induced oocyte meiotic resumption, regulation, overview. The enzyme is involved in CREB phosphorylation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.154 oocyte
-
 Mus musculus
-
1.14.14.154 ovarian cumulus cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 additional information the enzyme is involved in follicle-stimulating hormone-induced mouse oocyte maturation and follicle-stimulating hormone-induced oocyte meiotic resumption, regulation, overview. The enzyme is involved in CREB phosphorylation Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 cytochrome P450 lanosterol 14alpha-demethylase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.154 cytochrome P450 a cytochrome P450 enzyme Mus musculus