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Literature summary extracted from

  • Kim, S.; Park, D.H.; Shim, J.
    Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans (2008), Mol. Cells, 26, 344-349.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 5-fluorouracil
-
 Caenorhabditis elegans

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.1 Caenorhabditis elegans
-
-
-
1.3.1.1 Caenorhabditis elegans Bristol N2
-
-
-
2.1.1.45 Caenorhabditis elegans
-
-
-
2.1.1.45 Caenorhabditis elegans Bristol N2
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.45 embryo
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.1 5-fluorouracil + NADH + H+
-
 Caenorhabditis elegans 5-fluoro-5,6-dihydrouracil + NAD+
-
 ?
1.3.1.1 5-fluorouracil + NADH + H+
-
 Caenorhabditis elegans Bristol N2 5-fluoro-5,6-dihydrouracil + NAD+
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Caenorhabditis elegans dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Caenorhabditis elegans Bristol N2 dihydrofolate + dTMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.1 dihydropyrimidine dehydrogenase
-
 Caenorhabditis elegans
1.3.1.1 DPD
-
 Caenorhabditis elegans
2.1.1.45 Y110A7A.4
-
 Caenorhabditis elegans

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.1 NAD+
-
 Caenorhabditis elegans
2.1.1.45 N5,N10-methylenetetrahydrofolate
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.1.1.45 physiological function thymidylate synthase plays an essential role in embryogenesis, embryos with their thymidylate synthase function inhibited show a retarded embryo development and irregular cell sizes Caenorhabditis elegans