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Literature summary extracted from

  • Tenno, M.; Ohtsubo, K.; Hagen, F.K.; Ditto, D.; Zarbock, A.; Schaerli, P.; von Andrian, U.H.; Ley, K.; Le, D.; Tabak, L.A.; Marth, J.D.
    Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity (2007), Mol. Cell. Biol., 27, 8783-8796.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.41 pIMKF3 for expression in COS7 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.41 delta/delta mice homozygous for ppGalNAcT-1delta allele Mus musculus
2.4.1.41 ppGalNAcT-1delta allele in transgenic mice that lacks exon 3 and enzymatic activity, crossed into C57BL/6NHsd background Mus musculus
2.4.1.41 wt/delta mice heterozygous for ppGalNAcT-1delta allele Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Mus musculus mucin-type O-linked glycosylation of serine or threonine residues UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Mus musculus
-
 isoform ppGalNAcT-1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.41 brain redundancy of enzyme activity Mus musculus
-
2.4.1.41 germinal center ppGalNacT-1 activity is essential for O-glycosylation in germinal center (GC) B cells within the white pulp of the spleen and lymph nodes upon immunization, increased apoptosis of IgG bearing GC B cells and reduced IgG abundance in the absence of ppGalNAcT-1 Mus musculus
-
2.4.1.41 kidney cloned from mouse kidney total RNA Mus musculus
-
2.4.1.41 leukocyte ppGalNAcT-1 mediated O-glycosylation contributes to innate immune inflammatory response among activated endothelial cells by expression of cell surface selectin ligands on neutrophils Mus musculus
-
2.4.1.41 lymph node mostly inguinal lymph nodes, not Peyerย’s patch tissue, ppGalNAcT-1 activity regulates L-selectin ligand level in high endothelial venules that is responsible for lymph node cellularity and B- and T-cell homing Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 UDP-GalNAc + EA2
-
 Mus musculus GalNAc-EA2 + UDP
-
 ?
2.4.1.41 UDP-GalNAc + PRFODSSSKAPPPLPSPSRLPG
-
 Mus musculus GalNAc-PRFODSSSKAPPPLPSPSRLPG + UDP
-
 ?
2.4.1.41 UDP-GalNAc + selectin
-
 Mus musculus GalNAc-selectin + UDP reduced expression of cell surface E- and P-selectins (fourfold and fivefold) and L-selectins on immune cells of ppGalNAcT-1 deficient mice ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide mucin-type O-linked glycosylation of serine or threonine residues Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.41 polypeptide GalNAc transferase
-
 Mus musculus
2.4.1.41 polypeptide GalNAcT
-
 Mus musculus
2.4.1.41 polypeptide N-acetylgalactosaminyltransferase
-
 Mus musculus
2.4.1.41 ppGalNAcT
-
 Mus musculus