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Literature summary extracted from

  • Miura, T.; Nishinaka, T.; Terada, T.
    Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1 (2008), Mol. Cell. Biochem., 315, 113-121.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.184 expression in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.184 0.038
-
 NADPH pH 6.5, 25°C Homo sapiens
1.1.1.184 0.043
-
 menadione pH 6.5, 25°C Homo sapiens
1.1.1.184 0.13
-
 4-nitrobenzaldehyde pH 6.5, 25°C Homo sapiens
1.1.1.184 0.3
-
 4-benzoylpyridine pH 6.5, 25°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.184 cytosol recombinant protein in HEK-293 cell Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.184 40000
-
 x * 40000, SDS-PAGE, His-tagged protein Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Homo sapiens O75828 isoform Cbr3, comparison with prostaglandin 9-ketoreductase Cbr1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.184 intestine
-
 Homo sapiens
-
1.1.1.184 ovary
-
 Homo sapiens
-
1.1.1.184 ovary lower expression in prostate and testis than in ovary Homo sapiens
-
1.1.1.184 pancreas
-
 Homo sapiens
-
1.1.1.184 prostate lower expression in prostate and testis than in ovary Homo sapiens
-
1.1.1.184 testis lower expression in prostate and testis than in ovary Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 4-benzoylpyridine + NADPH + H+
-
 Homo sapiens (S)-alpha-phenyl-4-pyridylmethanol + NADP+
-
 ?
1.1.1.184 4-nitrobenzaldehyde + NADPH
-
 Homo sapiens 4-nitrobenzyl alcohol + NADP+
-
 ?
1.1.1.184 menadione + NADPH
-
 Homo sapiens ? + NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.184 ? x * 40000, SDS-PAGE, His-tagged protein Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.184 0.0092
-
 menadione pH 6.5, 25°C Homo sapiens
1.1.1.184 0.0098
-
 4-nitrobenzaldehyde pH 6.5, 25°C Homo sapiens
1.1.1.184 0.012
-
 4-benzoylpyridine pH 6.5, 25°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.184 5.5 7
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.184 4
-
 15% of maximum activity Homo sapiens
1.1.1.184 8
-
 35% of maximum activity Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.184 NAD+
-
 Homo sapiens
1.1.1.184 NADH with NADH, about 45% of the activity with NADPH Homo sapiens
1.1.1.184 NADP+
-
 Homo sapiens
1.1.1.184 NADPH with NADH, about 45% of the activity with NADPH Homo sapiens