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Literature summary extracted from

  • Jimenez-Jimenez, C.; Carrero-Lerida, J.; Sealey-Cardona, M.; Ruiz Perez, L.M.; Urbina, J.A.; Gonzalez Pacanowska, D.
    Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme (2008), Mol. Biochem. Parasitol., 160, 52-59.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.41 additional information Leishmania major promastigotes cells overproducing the enzyme do not have increased resistance to the sterol methenyltransferase inhibitor 22,26-azasterol Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.41 22,26-azasterol
-
 Leishmania major
2.1.1.41 ketoconazole
-
 Leishmania major

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.41 endoplasmic reticulum by immunofluorescence and electron microscopy studies it is shown that sterol methenyltransferase is primarily associated to the endoplasmic reticulum. In addition to this localisation, the protein is incorporated into translucent vesicles presumably of the endocytic pathway Leishmania major 5783
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.41 Leishmania major
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.41 desmosterol + S-adenosyl-L-methionine
-
 Leishmania major 24-methylenedesmosterol + S-adenosyl-L-homocysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.41 SMT
-
 Leishmania major

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.41 0.0035
-
-
 Leishmania major 22,26-azasterol
2.1.1.41 0.00383
-
-
 Leishmania major ketoconazole