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Literature summary extracted from

  • Chambers, J.W.; Fowler, M.L.; Morris, M.T.; Morris, J.C.
    The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1 (2008), Mol. Biochem. Parasitol., 158, 202-207.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.1 medicine TbHK1 is a valid therapeutic target while identifying a potential molecular target of the anti-trypanosomal agent lonidamine Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 lonidamine lonidamine is toxic to cultured bloodstream form parasites and procyclic form parasites. Overexpression of TbHK1 protects procyclic forms from lonidamine Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Trypanosoma brucei
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 bloodstream form TbHK1 is essential to the bloodstream form. Silencing the gene for 4 days reduces cellular hexokinase about 60% and leads to parasite death Trypanosoma brucei
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Synonyms

EC Number Synonyms Comment Organism
2.7.1.1 hexokinase 1
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 Trypanosoma brucei
2.7.1.1 TbHK1
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 Trypanosoma brucei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.1 0.85
-
 recombinant enzyme Trypanosoma brucei lonidamine