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Literature summary extracted from
- Kinetic characterization of inosine monophosphate dehydrogenase of Leishmania donovani (2007), Mol. Biochem. Parasitol., 152, 11-21.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.205 | expression in Escherichia coli | Leishmania donovani |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.205 | GMP | - |
Leishmania donovani |  |
| 1.1.1.205 | Mycophenolic acid | - |
Leishmania donovani | |
| 1.1.1.205 | XMP | - |
Leishmania donovani | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.205 | 0.033 | - |
inosine 5'-phosphate | pH 7.5, 25°C | Leishmania donovani | |
| 1.1.1.205 | 0.39 | - |
NAD+ | pH 7.5, 25°C | Leishmania donovani | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.205 | glycosome | - |
Leishmania donovani | 20015 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.205 | 55000 | - |
4 * 55000, SDS-PAGE | Leishmania donovani |
| 1.1.1.205 | 204000 | - |
gel filtration | Leishmania donovani |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.205 | Leishmania donovani | - |
- |
- |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.1.1.205 | -80°C, purified protein remains active for more than 18 months | Leishmania donovani |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.205 | inosine 5'-phosphate + NAD+ + H2O | enzyme is highly specific for both inosine 5'-phosphate and NAD+ | Leishmania donovani | xanthosine 5'-phosphate + NADH | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.205 | More | IMPDH associates tightly with glycosomal protein sorting receptor PEX5 | Leishmania donovani |
| 1.1.1.205 | tetramer | 4 * 55000, SDS-PAGE | Leishmania donovani |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.205 | 0.000025 | - |
Mycophenolic acid | pH 7.5, 25°C | Leishmania donovani | |
| 1.1.1.205 | 0.026 | - |
XMP | pH 7.5, 25°C | Leishmania donovani | |
| 1.1.1.205 | 0.21 | - |
GMP | pH 7.5, 25°C | Leishmania donovani | |
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Release 2023.1 (January 2023)
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