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Literature summary extracted from

  • Hargreaves, I.P.; Duncan, A.J.; Wu, L.; Agrawal, A.; Land, J.M.; Heales, S.J.
    Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies (2007), Mitochondrion, 7, 284-287.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.9 medicine evidence of secondary loss of electron transport chain function (loss of complex II-III activity) resulting from a primary electron transport chain deficiency (of complex IV), which provides a possible mechanism for the progressive nature of mitochondrial encephalomyopathies and why in some patients multiple patterns of electron transport chain deficiencies may be demonstrated Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 KCN 1 mM results in a sustained 50% loss of activity following 24, 48 and 72 h of culture Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 mitochondrion
-
 Homo sapiens 5739
-
7.1.1.9 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.1 additional information Homo sapiens inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies, overview ?
-
 ?
1.3.5.1 succinate + ubiquinone Homo sapiens
-
 fumarate + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Homo sapiens
-
-
-
7.1.1.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.5.1 astrocytoma cell
-
 Homo sapiens
-
7.1.1.9 additional information 1321N cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 additional information inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies, overview Homo sapiens ?
-
 ?
1.3.5.1 succinate + ubiquinone
-
 Homo sapiens fumarate + ubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.5.1 mitochondrial complex II
-
 Homo sapiens
7.1.1.9 cytochrome oxidase
-
 Homo sapiens