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Literature summary extracted from

  • Newton, G.L.; Buchmeier, N.; Fahey, R.C.
    Biosynthesis and functions of mycothiol, the unique protective thiol of actinobacteria (2008), Microbiol. Mol. Biol. Rev., 72, 471-494.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.189 desacetylmycothiol + acetyl-CoA Mycolicibacterium smegmatis last step in biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA Corynebacterium glutamicum last step in biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA Streptomyces coelicolor last step in biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA Rhodococcus jostii last step in biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA Mycobacterium tuberculosis last step in biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA Rhodococcus jostii RHA-1 last step in biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA Mycobacterium tuberculosis H37Rv last step in biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme A
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.15 Mycobacterium tuberculosis
-
-
-
2.3.1.189 Corynebacterium glutamicum
-
-
-
2.3.1.189 Mycobacterium tuberculosis P9WJM7
-
-
2.3.1.189 Mycobacterium tuberculosis H37Rv P9WJM7
-
-
2.3.1.189 Mycolicibacterium smegmatis
-
-
-
2.3.1.189 Rhodococcus jostii
-
 RHA-1
-
2.3.1.189 Rhodococcus jostii RHA-1
-
 RHA-1
-
2.3.1.189 Streptomyces coelicolor
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.15 AcCys-GlcN + NADPH
-
 Mycobacterium tuberculosis ?
-
 ?
1.8.1.15 AcCys-GlcN-1-O-CH2Ph + NADPH
-
 Mycobacterium tuberculosis ?
-
 ?
1.8.1.15 AcCys-GlcN-1-O-CH3 + NADPH
-
 Mycobacterium tuberculosis ?
-
 ?
1.8.1.15 des-myo-inositol mycothione + NADH
-
 Mycobacterium tuberculosis ?
-
 ?
1.8.1.15 mycothione + NADPH
-
 Mycobacterium tuberculosis mycothiol + NADP+
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Mycolicibacterium smegmatis mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Corynebacterium glutamicum mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Streptomyces coelicolor mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Rhodococcus jostii mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Mycobacterium tuberculosis mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA last step in biosynthesis of mycothiol, the major thiol in most actinomycetes Mycolicibacterium smegmatis mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA last step in biosynthesis of mycothiol, the major thiol in most actinomycetes Corynebacterium glutamicum mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA last step in biosynthesis of mycothiol, the major thiol in most actinomycetes Streptomyces coelicolor mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA last step in biosynthesis of mycothiol, the major thiol in most actinomycetes Rhodococcus jostii mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA last step in biosynthesis of mycothiol, the major thiol in most actinomycetes Mycobacterium tuberculosis mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Rhodococcus jostii RHA-1 mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA last step in biosynthesis of mycothiol, the major thiol in most actinomycetes Rhodococcus jostii RHA-1 mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Mycobacterium tuberculosis H37Rv mycothiol + coenzyme A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA last step in biosynthesis of mycothiol, the major thiol in most actinomycetes Mycobacterium tuberculosis H37Rv mycothiol + coenzyme A
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.15 MSH disulfide reductase
-
 Mycobacterium tuberculosis
1.8.1.15 MTR
-
 Mycobacterium tuberculosis
1.8.1.15 mycothione reductase
-
 Mycobacterium tuberculosis
2.3.1.189 MSH acetyltransferase
-
 Mycolicibacterium smegmatis
2.3.1.189 MSH acetyltransferase
-
 Corynebacterium glutamicum
2.3.1.189 MSH acetyltransferase
-
 Streptomyces coelicolor
2.3.1.189 MSH acetyltransferase
-
 Rhodococcus jostii
2.3.1.189 MSH acetyltransferase
-
 Mycobacterium tuberculosis
2.3.1.189 MSH synthase
-
 Mycolicibacterium smegmatis
2.3.1.189 MSH synthase
-
 Corynebacterium glutamicum
2.3.1.189 MSH synthase
-
 Streptomyces coelicolor
2.3.1.189 MSH synthase
-
 Rhodococcus jostii
2.3.1.189 MSH synthase
-
 Mycobacterium tuberculosis
2.3.1.189 MshD
-
 Streptomyces coelicolor
2.3.1.189 MshD
-
 Mycolicibacterium smegmatis
2.3.1.189 MshD
-
 Rhodococcus jostii
2.3.1.189 MshD
-
 Mycobacterium tuberculosis
2.3.1.189 nshD
-
 Corynebacterium glutamicum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.1.15 20
-
 NADH 25°C Mycobacterium tuberculosis
1.8.1.15 129
-
 NADPH 25°C Mycobacterium tuberculosis
1.8.1.15 190
-
 NADP+ 25°C Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.15 FAD
-
 Mycobacterium tuberculosis
1.8.1.15 NADPH
-
 Mycobacterium tuberculosis