Any feedback?
Literature summary extracted from
- A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation (2008), Mem. Inst. Oswaldo Cruz, 103, 263-270.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.1.12 | medicine | hypnophilin is good candidate for developing new drugs against Chagas disease | Trypanosoma cruzi |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.12 | crude extract of Lentinus strigosus | 100% inhibition of trypanothione reductase | Trypanosoma cruzi | |
| 1.8.1.12 | dihydrohypnophilin | no inhibitory activity | Trypanosoma cruzi |  |
| 1.8.1.12 | hypnophilin | 100% inhibition of trypanothione reductase, reduces the proliferation of human peripheral blood monocluear cells, not cytotoxic for lymphocytes and monocytes | Trypanosoma cruzi | |
| 1.8.1.12 | additional information | neopanepoxydol has no inhibitory activity | Trypanosoma cruzi | |
| 1.8.1.12 | panepoxydone | 95% inhibition of trypanothione reductase | Trypanosoma cruzi | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.12 | Trypanosoma cruzi | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.12 | trypanothione + 5,5'-dithiobis-(2-nitrobenzoic acid) | - |
Trypanosoma cruzi | trypanothione disulfide + thionitrobenzoate | - |
? | |
| 1.8.1.12 | trypanothione + NADP+ | - |
Trypanosoma cruzi | trypanothione disulfide + NADPH + H+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.12 | trypanothione reductase | TR | Trypanosoma cruzi |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.12 | 0.0008 | - |
using recombinant trypanothione reductase from Trypanosoma cruzi | Trypanosoma cruzi | hypnophilin | |
| 1.8.1.12 | 0.0025 | - |
assay with Trypanosoma cruzi amastigotes | Trypanosoma cruzi | hypnophilin | |
| 1.8.1.12 | 0.0389 | - |
- |
Trypanosoma cruzi | panepoxydone | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
