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Literature summary extracted from

  • Taja-Chayeb, L.; Vidal-Millan, S.; Gutierrez, O.; Ostrosky-Wegman, P.; Duenas-Gonzalez, A.; Candelaria, M.
    Thiopurine S-methyltransferase gene (TMPT) polymorphisms in a Mexican population of healthy individuals and leukemic patients (2008), Med. Oncol., 25, 56-62.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine polymorphisms at the thiopurine S-methyltransferase coding gene determine enzyme activity and consequently, the development of toxicity secondary to thiopurines Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.67 A154Y thiopurine S-methyltransferase polymorphism, G to A transition at position 460 Homo sapiens
2.1.1.67 A80P thiopurine S-methyltransferase polymorphism, G to C transition at position 238 Homo sapiens
2.1.1.67 Y240C thiopurine S-methyltransferase polymorphism, A to G transition at position 719 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.67 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 leukocyte peripheral blood leukocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens ?
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens ?
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + azathioprine
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine S-methyltransferase
-
 Homo sapiens
2.1.1.67 TMPT
-
 Homo sapiens