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Literature summary extracted from

  • Zollner, G.; Wagner, M.; Fickert, P.; Silbert, D.; Gumhold, J.; Zatloukal, K.; Denk, H.; Trauner, M.
    Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis (2007), Liver Int., 27, 920-929.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.139 expression analysis in healthy livers and liver with primary biliary cirrhosis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens the enzyme is involved in bile acid synthesis, repression of bile acid synthesis and induction of basolateral bile acid export may represent adaptive mechanisms to limit bile acid burden in chronic cholestasis, but the changes do not sufficiently counteract cholestatic liver damage, overview 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 additional information Homo sapiens the enzyme expression is not affected by primary biliary cirrhosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.139 liver the enzyme expression is not affected by primary biliary cirrhosis Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme is involved in bile acid synthesis, repression of bile acid synthesis and induction of basolateral bile acid export may represent adaptive mechanisms to limit bile acid burden in chronic cholestasis, but the changes do not sufficiently counteract cholestatic liver damage, overview Homo sapiens 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 additional information the enzyme expression is not affected by primary biliary cirrhosis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 CYP8B1
-
 Homo sapiens