Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Miike, T.; Shirahase, H.; Jino, H.; Kunishiro, K.; Kanda, M.; Kurahashi, K.
    Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells (2008), Life Sci., 82, 79-84.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.26 medicine an anti-oxidative ACAT inhibitor or the combination of an antioxidant and an ACAT inhibitor protects foam cells from oxidative stress and effectively reduces cholesterol levels, which would be a promising approach in anti-atherosclerotic therapy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 N-(4,6-dimethyl-1-pentylindolin-7-yl)-2,2-dimethylpropanamide KY-455, an anti-oxidative ACAT inhibitor Homo sapiens
2.3.1.26 YM-750
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 THP-1 cell THP-1 cell-derived foam cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT
-
 Homo sapiens
2.3.1.26 acyl-CoA:cholesterol acyltransferase
-
 Homo sapiens