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Literature summary extracted from

  • Gong, R.; Morris, D.J.; Brem, A.S.
    Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2 (2008), Life Sci., 82, 631-637.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.B40 0.0000102
-
 NAD+ kidney homogenate, pH and temperature not specified in the publication Homo sapiens
1.1.1.146 0.0000102
-
 NAD+ isoform 11beta-HSD2, kidney homogenate Homo sapiens
1.1.1.146 0.00042
-
 NADP+ isoform 11beta-HSD1, kidney homogenate Homo sapiens
1.1.1.146 0.00042
-
 NADP+ kidney homogenate, pH and temperature not specified in the publication Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
-
-
1.1.1.146 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 kidney similar amounts of protein for both isoform 11beta-HSD1 and 11beta-HSD2. 11beta-HSD1 functions as a dehydrogenase with no significant reverse reductase activity and colocalizes with cyclooxygenase COX-2 in proximal tubule cells. No colocalization of COX-2 with isoform 11beta-HSD2 in cortical collecting duct Homo sapiens
-
1.1.1.146 kidney similar amounts of protein for both isoform 11beta-HSD1 and 11beta-HSD2. 11beta-HSD1 functions as a dehydrogenase with no significant reverse reductase activity and colocalizes with cyclooxygenase COX-2 in proximal tubule cells. No colocalization of COX-2 with isoform 11beta-HSD2 in cortical collecting duct Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+
-
 Homo sapiens cortisone + NADH
-
 ?
1.1.1.146 cortisol + NAD+ isoform 11beta-HSD2 Homo sapiens cortisone + NADH
-
 ?
1.1.1.146 cortisol + NADP+
-
 Homo sapiens cortisone + NADPH
-
 ?
1.1.1.146 cortisol + NADP+ isoform 11beta-HSD1 Homo sapiens cortisone + NADPH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD2
-
 Homo sapiens
1.1.1.B40 11beta-hydroxysteroid dehydrogenase 2
-
 Homo sapiens
1.1.1.146 11beta-HSD1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Homo sapiens
1.1.1.146 NADP+
-
 Homo sapiens