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Literature summary extracted from

  • Barbosa, R.; Scialfa, J.H.; Terra, I.M.; Cipolla-Neto, J.; Simonneaux, V.; Afeche, S.C.
    Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland (2008), Life Sci., 82, 529-535.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.16.4 DTT
-
Rattus norvegicus
1.14.16.4 additional information the calcium influx through L-type high voltage-activated calcium channels is essential for the full activation of tryptophan hydroxylase leading to melatonin synthesis in the pineal gland Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.4 nifedipine reduces the enzyme activity by blocking the Ca2+-influx accompanied with a reduction of 5-hydroxytryptophan, serotonin, N-acetylserotonin and melatonin intracellular content, as well as a reduction of serotonin and melatonin secretion Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.16.4 Ca2+ the calcium influx through L-type high voltage-activated calcium channels is essential for the full activation of tryptophan hydroxylase leading to melatonin synthesis in the pineal gland Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus the calcium influx through L-type high voltage-activated calcium channels is essential for the full activation of tryptophan hydroxylase leading to melatonin synthesis in the pineal gland 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.4 Rattus norvegicus
-
male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.4 pineal gland
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.4 L-tryptophan + 6-methyl-tetrahydrobiopterin + O2
-
Rattus norvegicus 5-hydroxy-L-tryptophan + 6-methyl-4a-hydroxytetrahydrobiopterin
-
?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2
-
Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 the calcium influx through L-type high voltage-activated calcium channels is essential for the full activation of tryptophan hydroxylase leading to melatonin synthesis in the pineal gland Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.16.4 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.16.4 7
-
assay at Rattus norvegicus