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Literature summary extracted from

  • Pancetti, F.; Olmos, C.; Dagnino-Subiabre, A.; Rozas, C.; Morales, B.
    Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase (2007), J. Toxicol. Environ. Health B Crit. Rev., 10, 623-630.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.19.1 medicine inhibition of acylpeptide hydrolase activity is related to cognitive improvement. Potential biomarker for organophosphate exposure in the screening for neurotoxicity. Possible participation of acylpeptide hydrolase in processes of synaptic plasticity. May play a predominant role in the control of presynaptic biopeptide concentrations that are contained in synaptic vesicles and released to the synaptic space exerting a neuromodular effect at a postsynaptic level Sus scrofa
3.4.19.1 medicine reliable biomarker for some organophosphate pesticides that show higher specificity for acylpeptide hydrolase than for cholinesterases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.1 dichlorvos shows selectivity for acylpeptide hydrolase inhibition in vivo Homo sapiens
3.4.19.1 dichlorvos exhibits high affinity for acylpeptide hydrolase, possibly blocks its activity toward N-acylpeptide Sus scrofa
3.4.19.1 diisopropyl fluorophosphate
-
Homo sapiens
3.4.19.1 diisopropyl fluorophosphate
-
Sus scrofa
3.4.19.1 additional information acylpeptide hydrolase is a direct target for some organophosphate compounds Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.1 Homo sapiens
-
-
-
3.4.19.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.1 brain
-
Sus scrofa
-
3.4.19.1 erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.1 N-acylpeptide + H2O acylpeptide hydrolase catalyzes the hydrolysis of short peptides of the type Nalpha-acyl to form an acyl amino acid and a peptide with a free N-terminus Sus scrofa ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.19.1 acylpeptide hydrolase
-
Homo sapiens
3.4.19.1 acylpeptide hydrolase
-
Sus scrofa