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Literature summary extracted from

  • Keller, B.; Adamski, J.
    RDH12, a retinol dehydrogenase causing Lebers congenital amaurosis, is also involved in steroid metabolism (2007), J. Steroid Biochem. Mol. Biol., 104, 190-194.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.150 expression in HeLa cell and 293T cell Mus musculus
1.1.1.150 expression in HeLa cell and 293T cell Homo sapiens
1.1.1.300 expression in HeLa cell and 293T cell Mus musculus
1.1.1.300 expression in HeLa cell and 293T cell Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.150 endoplasmic reticulum
-
 Mus musculus 5783
-
1.1.1.150 endoplasmic reticulum isoform RDH12 Homo sapiens 5783
-
1.1.1.150 mitochondrion isoform RDH13 Homo sapiens 5739
-
1.1.1.300 endoplasmic reticulum
-
 Mus musculus 5783
-
1.1.1.300 endoplasmic reticulum isoform RDH12 Homo sapiens 5783
-
1.1.1.300 mitochondrion isoform RDH13 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.150 Homo sapiens
-
 retinol dehydrogenase isoforms RDH12 and RDH13
-
1.1.1.150 Mus musculus
-
 retinol dehydrogenase isoform RDH12
-
1.1.1.300 Homo sapiens
-
 isoforms RDH12 and RDH13
-
1.1.1.300 Mus musculus
-
 isoform RDH12
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.150 dihydrotestosterone + NADH substrate for retinol dehydrogenase isoform RDH12, no substrate for isoform RDH13 Homo sapiens androstanediol + NAD+
-
 ?
1.1.1.150 additional information contrary to the human enzyme, dihydrotestosterone is not a substrate for mouse retinol dehydrogenase isoform RDH12 Mus musculus ?
-
 ?
1.1.1.300 additional information dihydrotestosterone is not a substrate for mouse isoform RDH12 Mus musculus ?
-
 ?
1.1.1.300 additional information isoform RDH12 additionally cataylzes the reduction of dihydrotestosterone to androstanediol Homo sapiens ?
-
 ?