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Literature summary extracted from

  • Toyama, T.; Kudo, N.; Mitsumoto, A.; Hibino, Y.; Tsuda, T.; Kawashima, Y.
    Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats (2007), J. Pharmacol. Sci., 103, 383-390.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.1 additional information treatment of rats with 2-(4-chlorophenoxy)-2-methylpropionic acid, i.e. clofibric acid, or feeding of a fat-free diet markedly elevated hepatic activity of SCD by increasing the steady-state level of SCD1 mRNA and enhancing transcriptional rate, metabolic effects, overview Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.1 SCD1, realtime-PCR-based quantitative expression analysis Rattus norvegicus
1.14.19.1 SCD2, realtime-PCR-based quantitative expression analysis Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 additional information Rattus norvegicus decreased degradation of SCD is responsible for the increase in palmitoyl-CoA chain elongase activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid, overview ?
-
 ?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
 oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Rattus norvegicus P07308 SCD1
-
1.14.19.1 Rattus norvegicus Q6P7B9 SCD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 additional information decreased degradation of SCD is responsible for the increase in palmitoyl-CoA chain elongase activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid, overview Rattus norvegicus ?
-
 ?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Rattus norvegicus oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD
-
 Rattus norvegicus
1.14.19.1 SCD2
-
 Rattus norvegicus
1.14.19.1 stearoyl-CoA desaturase
-
 Rattus norvegicus
1.14.19.1 stearoyl-CoA desaturase 2
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.19.1 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.19.1 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 ferrocytochrome b5
-
 Rattus norvegicus