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Literature summary extracted from

  • Gharavi, N.; El-Kadi, A.O.
    Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide (2007), J. Pharm. Sci., 96, 2795-2807.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.10 beta-naphthoflavone
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.10 (N-methyl-4'-pyridyl) porphyrin iron tetrakis, FeTMPyP, no inhibitory activity Mus musculus
1.6.5.10 L-N6-(1-iminoethyl) lysine no inhibitory activity Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.10 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.10 Hepa-1c1c7 cell
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.5.10 0.0005
-
 medium alone Mus musculus
1.6.5.10 0.0007
-
 TNFalpha and LPS inhibit the beta-naphthoflavone induced increase in activity Mus musculus
1.6.5.10 0.0012
-
 in presence of beta-naphthoflavone Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.10 NADPH + H+ + quinone TNF alpha and LPS induce Nqo1 mRNA expression Mus musculus NADP+ + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.10 NADPH:quinone oxidoreductase 1
-
 Mus musculus
1.6.5.10 NQO1
-
 Mus musculus