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Literature summary extracted from

  • Li, Y.; Mezei, O.; Shay, N.F.
    Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones (2007), J. Nutr., 137, 1705-1712.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.139 additional information hepatocyte nuclear factor 4a strongly induces the enzyme, the enzyme expression is induced by soybean isoflavones, e.g. genistein, daidzein, and glycitein, in both female and male mice, intake of soy isoflavones plus fenofibrate does not increase CYP8B1 mRNA levels in females, whereas there was an obvious upregulation in males, presence of PPARa inhibits isoflavone upregulation of CYP8B1 in cotransfected HepG2 cells, mechanism modeling, overview Mus musculus
1.14.14.139 additional information hepatocyte nuclear factor 4a strongly induces the enzyme, the enzyme expression is induced by soybean isoflavones, e.g. genistein, daidzein, and glycitein, presence of PPARa inhibits isoflavone upregulation of CYP8B1 in cotransfected HepG2 cells, mechanism modeling, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.139 expression analysis in response to soy bean isoflavones, transient expression in Hep-G2 cells Mus musculus
1.14.14.139 expression analysis in response to soy bean isoflavones, transient expression in Hep-G2 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.139 additional information the enzyme expression is suppressed by cholesterol, bile acids, and insulin via activation of small heterodimer partner, a universal repressor, by ligand-bound farnesoid x receptor Homo sapiens
1.14.14.139 additional information the enzyme expression is suppressed by cholesterol, bile acids, and insulin via activation of small heterodimer partner, a universal repressor, by ligand-bound farnesoid x receptor Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 additional information Mus musculus CYP8B1 is reportedly regulated by PPARalpha, overview ?
-
 ?
1.14.14.139 additional information Homo sapiens CYP8B1 is reportedly regulated by PPARalpha, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Homo sapiens
-
-
-
1.14.14.139 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.139 hepatocyte primary Mus musculus
-
1.14.14.139 hepatocyte primary Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 additional information CYP8B1 is reportedly regulated by PPARalpha, overview Mus musculus ?
-
 ?
1.14.14.139 additional information CYP8B1 is reportedly regulated by PPARalpha, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 12-alpha-hydroxylase
-
 Mus musculus
1.14.14.139 12-alpha-hydroxylase
-
 Homo sapiens
1.14.14.139 CYP8B1
-
 Mus musculus
1.14.14.139 CYP8B1
-
 Homo sapiens