EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.139 | additional information | hepatocyte nuclear factor 4a strongly induces the enzyme, the enzyme expression is induced by soybean isoflavones, e.g. genistein, daidzein, and glycitein, in both female and male mice, intake of soy isoflavones plus fenofibrate does not increase CYP8B1 mRNA levels in females, whereas there was an obvious upregulation in males, presence of PPARa inhibits isoflavone upregulation of CYP8B1 in cotransfected HepG2 cells, mechanism modeling, overview | Mus musculus | |
1.14.14.139 | additional information | hepatocyte nuclear factor 4a strongly induces the enzyme, the enzyme expression is induced by soybean isoflavones, e.g. genistein, daidzein, and glycitein, presence of PPARa inhibits isoflavone upregulation of CYP8B1 in cotransfected HepG2 cells, mechanism modeling, overview | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.139 | expression analysis in response to soy bean isoflavones, transient expression in Hep-G2 cells | Mus musculus |
1.14.14.139 | expression analysis in response to soy bean isoflavones, transient expression in Hep-G2 cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.139 | additional information | the enzyme expression is suppressed by cholesterol, bile acids, and insulin via activation of small heterodimer partner, a universal repressor, by ligand-bound farnesoid x receptor | Homo sapiens | |
1.14.14.139 | additional information | the enzyme expression is suppressed by cholesterol, bile acids, and insulin via activation of small heterodimer partner, a universal repressor, by ligand-bound farnesoid x receptor | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Mus musculus | - |
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.139 | additional information | Mus musculus | CYP8B1 is reportedly regulated by PPARalpha, overview | ? | - |
? | |
1.14.14.139 | additional information | Homo sapiens | CYP8B1 is reportedly regulated by PPARalpha, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.139 | Homo sapiens | - |
- |
- |
1.14.14.139 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.139 | hepatocyte | primary | Mus musculus | - |
1.14.14.139 | hepatocyte | primary | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.139 | additional information | CYP8B1 is reportedly regulated by PPARalpha, overview | Mus musculus | ? | - |
? | |
1.14.14.139 | additional information | CYP8B1 is reportedly regulated by PPARalpha, overview | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.139 | 12-alpha-hydroxylase | - |
Mus musculus |
1.14.14.139 | 12-alpha-hydroxylase | - |
Homo sapiens |
1.14.14.139 | CYP8B1 | - |
Mus musculus |
1.14.14.139 | CYP8B1 | - |
Homo sapiens |