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Literature summary extracted from

  • Cruz, F.; Edmondson, D.E.
    Kinetic properties of recombinant MAO-A on incorporation into phospholipid nanodisks (2007), J. Neural Transm., 114, 699-702.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 isatin
-
 Homo sapiens
1.4.3.4 p-(propylthio)-phenylisopropylamine
-
 Homo sapiens
1.4.3.4 phentermine
-
 Homo sapiens
1.4.3.4 rasagiline
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 0.02
-
 kynuramine pH 7.5, MAO-A incorporated into phospholipid nanodisks Homo sapiens
1.4.3.4 0.13
-
 kynuramine pH 7.5, detergent solubilized MAO-A Homo sapiens
1.4.3.4 0.49
-
 Phenylethylamine pH 7.5, MAO-A incorporated into phospholipid nanodisks Homo sapiens
1.4.3.4 1.48
-
 Phenylethylamine pH 7.5, detergent solubilized MAO-A Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P21397
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 phenylethylamine + H2O + O2
-
 Homo sapiens 2-phenylethanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Homo sapiens
1.4.3.4 monoamine oxidase A
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.4 0.897
-
 Phenylethylamine pH 7.5, detergent solubilized MAO-A Homo sapiens
1.4.3.4 0.998
-
 Phenylethylamine pH 7.5, MAO-A incorporated into phospholipid nanodisks Homo sapiens
1.4.3.4 1.08
-
 kynuramine pH 7.5, MAO-A incorporated into phospholipid nanodisks Homo sapiens
1.4.3.4 2.08
-
 kynuramine pH 7.5, detergent solubilized MAO-A Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.000011
-
 p-(propylthio)-phenylisopropylamine pH 7.5, MAO-A incorporated into phospholipid nanodisks Homo sapiens
1.4.3.4 0.00003
-
 p-(propylthio)-phenylisopropylamine pH 7.5, detergent solubilized MAO-A Homo sapiens
1.4.3.4 0.0033
-
 rasagiline pH 7.5, MAO-A incorporated into phospholipid nanodisks Homo sapiens
1.4.3.4 0.0063
-
 isatin pH 7.5, MAO-A incorporated into phospholipid nanodisks Homo sapiens
1.4.3.4 0.0097
-
 rasagiline pH 7.5, detergent solubilized MAO-A Homo sapiens
1.4.3.4 0.015
-
 isatin pH 7.5, detergent solubilized MAO-A Homo sapiens
1.4.3.4 0.127
-
 phentermine pH 7.5, MAO-A incorporated into phospholipid nanodisks Homo sapiens
1.4.3.4 0.498
-
 phentermine pH 7.5, detergent solubilized MAO-A Homo sapiens