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Literature summary extracted from

  • Pak, V.V.; Koo, M.; Kim, M.J.; Yang, H.J.; Yun, L.; Kwon, D.Y.
    Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG-CoA reductase (2008), J. Mol. Recognit., 21, 224-232.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 GFPTGG competitive, effects on enzyme Michaelis-Menten kinetics, overview Rattus norvegicus
1.1.1.34 GLPTGG competitive Rattus norvegicus
1.1.1.34 additional information design, synthesis and evaluation of structure-based peptide inhibitors, computational methods, overview Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.34 0.068
-
hydroxymethylglutaryl-CoA
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+ Rattus norvegicus
-
mevalonate + NADP+ + CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+
-
Rattus norvegicus mevalonate + NADP+ + CoA
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMG-CoA reductase
-
Rattus norvegicus
1.1.1.34 HMGR
-
Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.34 0.023
-
hydroxymethylglutaryl-CoA
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.34 0.0064
-
GFPTGG
-
Rattus norvegicus