EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.6.3.1 | nitroglycerin | in vascular smooth muscle cells exposed to nitroglycerin for 6-24 h, NAD(P)H oxidase activity is increased, in spite of isoform nox1 downregulation | Rattus norvegicus |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.2.1.5 | additional information | ALDH2 may have antioxidant properties. Yeast ALDH significantly and dose-dependently attenuates HX/XO-generated O2S- signal | Saccharomyces cerevisiae |
1.2.1.5 | additional information | reduced ALDH-2 activity and expression leads to decreased nitroglycerin bioconversion. ALDH is an important physiological inhibitory factor of superoxide production | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.5 | benomyl | potent irreversible inhibitor of ALDH. Benomyl increases superoxide production as much as nitroglycerin | Rattus norvegicus | |
1.2.1.5 | nitroglycerin | induces nitrate tolerance. Expression and activity of ALDH-2 is decreased in nitrate-tolerant rats | Rattus norvegicus | |
1.6.3.1 | nitroglycerin | in rats treated with nitroglycerin for three days, superoxide production is increased in all aortic layers, while expression of isoforms nox1, nox2 and nox4 is significantly decreased. In vascular smooth muscle cells exposed to nitroglycerin for 6-24 h, NAD(P)H oxidase activity is increased, in spite of nox1 downregulation | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.5 | Rattus norvegicus | P11884 | male Wistar rats | - |
1.2.1.5 | Saccharomyces cerevisiae | - |
- |
- |
1.6.3.1 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.5 | aorta | - |
Rattus norvegicus | - |
1.2.1.5 | additional information | addition of ALDH to RASM cell homogenates significantly decreases NO consumption | Rattus norvegicus | - |
1.2.1.5 | smooth muscle | - |
Rattus norvegicus | - |
1.6.3.1 | aortic smooth muscle cell | commercial preparation | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.5 | benzaldehyde + NADP+ + H2O | - |
Saccharomyces cerevisiae | benzoate + NADPH + H+ | - |
? | |
1.2.1.5 | benzaldehyde + NADP+ + H2O | - |
Rattus norvegicus | benzoate + NADPH + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.5 | aldehyde dehydrogenase 2 | - |
Saccharomyces cerevisiae |
1.2.1.5 | aldehyde dehydrogenase 2 | - |
Rattus norvegicus |
1.2.1.5 | ALDH2 | - |
Saccharomyces cerevisiae |
1.2.1.5 | ALDH2 | - |
Rattus norvegicus |