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Literature summary extracted from

  • Takahashi, K.; Kasai, M.; Ohta, M.; Shoji, Y.; Kunishiro, K.; Kanda, M.; Kurahashi, K.; Shirahase, H.
    Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid (2008), J. Med. Chem., 51, 4823-4833.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate pactimibe sulfate Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome
-
 Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Oryctolagus cuniculus
-
 CoA + cholesterol ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.26 microsomes are prepared Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 adrenal gland
-
 Oryctolagus cuniculus
-
2.3.1.26 intestinal mucosa
-
 Oryctolagus cuniculus
-
2.3.1.26 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Oryctolagus cuniculus CoA + cholesterol ester
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol activity assay Oryctolagus cuniculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT
-
 Oryctolagus cuniculus
2.3.1.26 acyl-CoA:cholesterol acyltransferase
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.26 37
-
 activity assay Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.26 7.4
-
 activity assay Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.26 0.00069
-
 hepatic ACAT Oryctolagus cuniculus [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate
2.3.1.26 0.00072
-
 intestinal ACAT Oryctolagus cuniculus [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate
2.3.1.26 0.0019
-
 macrophage ACAT Oryctolagus cuniculus [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate
2.3.1.26 0.0159
-
 adrenal ACAT Oryctolagus cuniculus [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate