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Literature summary extracted from

  • Ferraris, D.; Duvall, B.; Ko, Y.S.; Thomas, A.G.; Rojas, C.; Majer, P.; Hashimoto, K.; Tsukamoto, T.
    Synthesis and biological evaluation of D-amino acid oxidase inhibitors (2008), J. Med. Chem., 51, 3357-3359.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 4-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 4-fluoro-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 5-bromo-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 5-iodo-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 5-nitro-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 6-chlorobenzo[d]isoxazol-3-ol potent, competitive inhibitor Rattus norvegicus
1.4.3.3 6-ethoxy-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 6-fluoro-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 6-methoxy-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 6-methyl-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 6-nitro-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 7-fluoro-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 7-fluoro-6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 7-methyl-1,2-benzisoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 benzo[d]isoxazol-3-ol
-
 Rattus norvegicus
1.4.3.3 additional information negligible DAAO inhibition with muscimol, (S)-AMPA, 6-chloro-3-methoxybenzo[d]isoxazole, and 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-serine + H2O + O2
-
 Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Rattus norvegicus
1.4.3.3 DAAO
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.3 0.000188
-
-
 Rattus norvegicus 6-chlorobenzo[d]isoxazol-3-ol
1.4.3.3 0.000269
-
-
 Rattus norvegicus 6-methyl-1,2-benzisoxazol-3-ol
1.4.3.3 0.000444
-
-
 Rattus norvegicus 6-fluoro-1,2-benzisoxazol-3-ol
1.4.3.3 0.000599
-
-
 Rattus norvegicus 5-bromo-1,2-benzisoxazol-3-ol
1.4.3.3 0.000722
-
-
 Rattus norvegicus 6-nitro-1,2-benzisoxazol-3-ol
1.4.3.3 0.00151
-
-
 Rattus norvegicus 5-iodo-1,2-benzisoxazol-3-ol
1.4.3.3 0.00188
-
-
 Rattus norvegicus benzo[d]isoxazol-3-ol
1.4.3.3 0.00257
-
-
 Rattus norvegicus 6-methoxy-1,2-benzisoxazol-3-ol
1.4.3.3 0.00295
-
-
 Rattus norvegicus 5-nitro-1,2-benzisoxazol-3-ol
1.4.3.3 0.005
-
-
 Rattus norvegicus 6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
1.4.3.3 0.00782
-
-
 Rattus norvegicus 4-fluoro-1,2-benzisoxazol-3-ol
1.4.3.3 0.023
-
-
 Rattus norvegicus 7-fluoro-1,2-benzisoxazol-3-ol
1.4.3.3 0.1
-
 IC50 above 0.1 mM Rattus norvegicus 4-(trifluoromethyl)-1,2-benzisoxazol-3-ol
1.4.3.3 0.1
-
 IC50 above 0.1 mM Rattus norvegicus 6-ethoxy-1,2-benzisoxazol-3-ol
1.4.3.3 0.1
-
 IC50 above 0.1 mM Rattus norvegicus 7-methyl-1,2-benzisoxazol-3-ol
1.4.3.3 0.1
-
 IC50 above 0.1 mM Rattus norvegicus 7-fluoro-6-(trifluoromethyl)-1,2-benzisoxazol-3-ol