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Literature summary extracted from

  • La Regina, G.; Silvestri, R.; Artico, M.; Lavecchia, A.; Novellino, E.; Befani, O.; Turini, P.; Agostinelli, E.
    New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity (2007), J. Med. Chem., 50, 922-931.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 (2R)-1-cyclohexyl-N-methyl-N-(1H-pyrrol-2-ylmethyl)propan-2-amine
-
 Bos taurus
1.4.3.4 (R)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 (R)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 1-phenyl-N-(1H-pyrrol-2-ylmethyl)methanamine
-
 Bos taurus
1.4.3.4 2-phenyl-N-(1H-pyrrol-2-ylmethyl)ethanamine
-
 Bos taurus
1.4.3.4 Clorgyline
-
 Bos taurus
1.4.3.4 L-deprenyl
-
 Bos taurus
1.4.3.4 moclobemide
-
 Bos taurus
1.4.3.4 N,1-dimethyl-N-prop-2-yn-1-yl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-(1-phenylethyl)-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-(1H-pyrrol-2-ylmethyl)prop-2-yn-1-amine
-
 Bos taurus
1.4.3.4 N-(2-cyclohexylethyl)-N-methyl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-(2-phenylethyl),N-methyl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-(3-phenylpropyl),N-methyl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-(4-phenylbutyl),N-methyl 1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-2-phenylethyl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-benzyl,N-methyl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-benzyl-1-(1-methyl-1H-pyrrol-2-yl)methanamine most selective MAO-A inhibitor Bos taurus
1.4.3.4 N-benzyl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-benzyl-N-methyl-1-(1-methyl-1H-pyrrol-2-yl)methanamine
-
 Bos taurus
1.4.3.4 N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°Cmost selective MAO-B inhibitor Bos taurus
1.4.3.4 N-methyl-1-phenyl-N-(1H-pyrrol-2-ylmethyl)ethanamine
-
 Bos taurus
1.4.3.4 N-methyl-2-phenyl-N-(1H-pyrrol-2-ylmethyl)ethanamine
-
 Bos taurus
1.4.3.4 N-methyl-3-phenyl-N-(1H-pyrrol-2-ylmethyl)propan-1-amine
-
 Bos taurus
1.4.3.4 N-methyl-4-phenyl-N-(1H-pyrrol-2-ylmethyl)butan-1-amine
-
 Bos taurus
1.4.3.4 N-methyl-N-(1-phenylethyl)-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-methyl-N-[(1-methyl-1H-pyrrol-2-yl)methyl]prop-2-yn-1-amine
-
 Bos taurus
1.4.3.4 N-phenyl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-prop-2-yn-1-yl-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-[(1R)-1-cyclohexylethyl]-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 N-[(1S)-1-cyclohexylethyl]-1H-pyrrole-2-carboxamide
-
 Bos taurus
1.4.3.4 selegiline
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Bos taurus P21398
-
-
1.4.3.4 Bos taurus P56560
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Bos taurus
1.4.3.4 MAO-B
-
 Bos taurus
1.4.3.4 monoamine oxidase A
-
 Bos taurus
1.4.3.4 monoamine oxidase B
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.0000017
-
 (R)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.000007
-
 N-(2-phenylethyl),N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00001
-
 (R,S)-N-methyl,N-(alpha-phenylethyl)-1H-pyrrole- 2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00002
-
 N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00002
-
 (R)-N-(alpha-cyclohexylethyl)-N-methyl,N-(pyrrol-2-ylmethyl)-amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00002
-
 (S)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00002
-
 N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00002
-
 N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.000024
-
 N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00003
-
 (R)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00004
-
 N-(3-phenylpropyl),N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00005
-
 N-methyl,N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00005
-
 N-methyl,N-(3-phenylpropyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.000054
-
 Clorgyline pH 7.4, 38°C Bos taurus
1.4.3.4 0.000055
-
 N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00009
-
 N-(4-phenylbutyl),N-methyl 1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0001
-
 (R,S)-N-methyl,N-(alpha-phenylethyl),N-(pyrrol-2-ylmethyl)-amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0001
-
 N-methyl,N-(3-phenylbutyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00012
-
 N-(2-phenylethyl),N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00015
-
 N-methyl,N-(benzyl),N-(1-methylpyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00023
-
 N-propargyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00025
-
 N-benzyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00026
-
 (R)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0003
-
 N-(propargyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00033
-
 (S)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00035
-
 N-(benzyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0004
-
 N-phenyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00042
-
 N-2-phenylethyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00044
-
 N-methyl,N-(propargyl),N-(1-methylpyrrol-2-ylmethyl)-amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0006
-
 N-benzyl,N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00062
-
 N-(propargyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0007
-
 N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0007
-
 N-methyl,N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.00083
-
 N-propargyl,N-methyl-1-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.00097
-
 selegiline pH 7.4, 38°C Bos taurus
1.4.3.4 0.00122
-
 (R,S)-N-(alpha-phenylethyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0015
-
 (R)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.002
-
 N-methyl,N-(3-phenylbutyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0025
-
 N-(4-phenylbutyl),N-methyl 1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0025
-
 (R,S)-N-(alpha-phenylethyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0035
-
 N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0036
-
 (S)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0038
-
 selegiline pH 7.4, 38°C Bos taurus
1.4.3.4 0.0041
-
 (S)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0045
-
 (R,S)-N-methyl,N-(alpha-phenylethyl),N-(pyrrol-2-ylmethyl)-amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0048
-
 N-methyl,N-(3-phenylpropyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.007
-
 (R)-N-(alpha-cyclohexylethyl)-N-methyl,N-(pyrrol-2-ylmethyl)-amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0072
-
 N-(benzyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.0089
-
 N-(3-phenylpropyl),N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.0115
-
 moclobemide pH 7.4, 38°C Bos taurus
1.4.3.4 0.025
-
 N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.057
-
 N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.058
-
 Clorgyline pH 7.4, 38°C Bos taurus
1.4.3.4 0.0618
-
 (R,S)-N-methyl,N-(alpha-phenylethyl)-1H-pyrrole- 2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.07
-
 N-propargyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.085
-
 N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus
1.4.3.4 0.15
-
 N-benzyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.15
-
 N-benzyl,N-methyl-1H-pyrrole-2-carboxamide pH 7.4, 38°C Bos taurus
1.4.3.4 0.3
-
 N-methyl,N-(benzyl),N-(1-methylpyrrol-2-ylmethyl)amine pH 7.4, 38°C Bos taurus