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Literature summary extracted from

  • Nencka, R.; Votruba, I.; Hrebabecky, H.; Jansa, P.; Tloustova, E.; Horska, K.; Masojidkova, M.; Holy, A.
    Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase (2007), J. Med. Chem., 50, 6016-6023.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.4 expressed in Chinese hamster V-79 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 5-butyl-6-chloropyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4-(1H,3H)-pyrimidine
-
 Homo sapiens
2.4.2.4 5-phenyl-6-pyrrolidin-1-ylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 5-[(1E)-but-1-en-1-yl]-6-chloropyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-bromo-5-phenylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-(1-methylethenyl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-(2-naphthyl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-(2-thienyl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-(3,5-dimethylphenyl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-(4-fluorophenyl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-cyclohex-1-en-1-ylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-cyclopent-1-en-1-yluracil
-
 Homo sapiens
2.4.2.4 6-chloro-5-ethylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-hexylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-pentylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-propylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-pyridin-3-ylpyrimidine-2,4(1H,3H)-dione hydrochloride
-
 Homo sapiens
2.4.2.4 6-chloro-5-[(1E)-1-ethylprop-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-[(1E)-pent-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-chloro-5-[(1E)-prop-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-methyl-5-phenylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.2.4 6-[(2-aminoethyl)amino]-5-phenylpyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.4 chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.4 gliostatin
-
 Homo sapiens
2.4.2.4 PD-ECGF
-
 Homo sapiens
2.4.2.4 platelet-derived endothelial cell growth factor
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.4 0.0000013
-
 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4-(1H,3H)-pyrimidine enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.0000021
-
 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4-(1H,3H)-pyrimidine enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.0002
-
 6-chloro-5-cyclopent-1-en-1-yluracil enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.0002
-
 5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00028
-
 6-chloro-5-(2-thienyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00029
-
 6-chloro-5-cyclopent-1-en-1-yluracil enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.0004
-
 6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00041
-
 6-chloro-5-[(1E)-pent-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00042
-
 6-chloro-5-cyclohex-1-en-1-ylpyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00043
-
 6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00047
-
 6-fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00049
-
 6-chloro-5-[(1E)-1-ethylprop-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.0005
-
 6-fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00054
-
 6-chloro-5-(2-thienyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00063
-
 5-[(1E)-but-1-en-1-yl]-6-chloropyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00071
-
 6-chloro-5-(4-fluorophenyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00075
-
 6-chloro-5-cyclohex-1-en-1-ylpyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00091
-
 6-chloro-5-[(1E)-1-ethylprop-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00091
-
 6-chloro-5-[(1E)-pent-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00092
-
 5-[(1E)-but-1-en-1-yl]-6-chloropyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00097
-
 6-chloro-5-(4-fluorophenyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00103
-
 5-butyl-6-chloropyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00106
-
 6-chloro-5-hexylpyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00117
-
 6-chloro-5-[(1E)-prop-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00121
-
 6-chloro-5-[(1E)-prop-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00121
-
 6-bromo-5-phenylpyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00121
-
 6-bromo-5-phenylpyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00127
-
 6-chloro-5-(3,5-dimethylphenyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.0016
-
 6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00165
-
 5-butyl-6-chloropyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00174
-
 6-chloro-5-(3,5-dimethylphenyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00179
-
 6-chloro-5-hexylpyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00301
-
 6-chloro-5-pyridin-3-ylpyrimidine-2,4(1H,3H)-dione hydrochloride enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00309
-
 6-chloro-5-pentylpyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00334
-
 6-chloro-5-(1-methylethenyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00367
-
 6-chloro-5-pentylpyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00394
-
 6-chloro-5-(2-naphthyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00399
-
 6-chloro-5-pyridin-3-ylpyrimidine-2,4(1H,3H)-dione hydrochloride enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00402
-
 6-chloro-5-propylpyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00455
-
 5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00459
-
 6-chloro-5-(2-naphthyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00465
-
 6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.0051
-
 6-chloro-5-(1-methylethenyl)pyrimidine-2,4(1H,3H)-dione enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.00581
-
 6-chloro-5-propylpyrimidine-2,4(1H,3H)-dione enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.02
-
 6-chloro-5-ethylpyrimidine-2,4(1H,3H)-dione Km above 0.02 mM, enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.02
-
 6-methyl-5-phenylpyrimidine-2,4(1H,3H)-dione Km above 0.02 mM, enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.02
-
 5-phenyl-6-pyrrolidin-1-ylpyrimidine-2,4(1H,3H)-dione Km above 0.02 mM, enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.02
-
 6-[(2-aminoethyl)amino]-5-phenylpyrimidine-2,4(1H,3H)-dione Km above 0.02 mM, enzyme purified from placenta, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.02
-
 6-chloro-5-ethylpyrimidine-2,4(1H,3H)-dione Km above 0.02 mM, enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.02
-
 6-methyl-5-phenylpyrimidine-2,4(1H,3H)-dione Km above 0.02 mM, enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.02
-
 5-phenyl-6-pyrrolidin-1-ylpyrimidine-2,4(1H,3H)-dione Km above 0.02 mM, enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens
2.4.2.4 0.02
-
 6-[(2-aminoethyl)amino]-5-phenylpyrimidine-2,4(1H,3H)-dione Km above 0.02 mM, enzyme purified from V79 cells, in 20 mM Bis-Tris-HCl (pH 6.4), at 37°C Homo sapiens