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Literature summary extracted from

  • Lopez-Parra, M.; Titos, E.; Horrillo, R.; Ferre, N.; Gonzalez-Periz, A.; Martinez-Clemente, M.; Planaguma, A.; Masferrer, J.L.; Arroyo, V.; Claria, J.
    Regulatory effects of arachidonate 5-lipoxygenase on hepatic MTP activity and VLDL-TG and ApoB secretion in obese mice (2008), J. Lipid Res., 49, 2513-2523.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.13.11.34 drug development the enzyme is an emerging target in obesity, insulin resistance, and artherosclerosis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus C57/BL6J
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2 Mus musculus
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 arachidonic acid + O2 Mus musculus C57/BL6J
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 additional information Mus musculus 5-LO inhibition in obese mice downregulates genes involved in hepatic fatty acid uptake, i.e. L-FABP and FAT/CD36, and normalizes PPARalpha and acyl-CoA oxidase expression, whereas the expression of lipogenic genes, i.e. FASN and SREBP-1c, remains unaltered. The 5-LO inhibition restores hepatic microsomal triglyceride transfer protein, MTP, activity in parallel with a stimulation of hepatic VLDL-TG and ApoB secretion in obese mice, overview ?
-
 ?
1.13.11.34 additional information Mus musculus C57/BL6J 5-LO inhibition in obese mice downregulates genes involved in hepatic fatty acid uptake, i.e. L-FABP and FAT/CD36, and normalizes PPARalpha and acyl-CoA oxidase expression, whereas the expression of lipogenic genes, i.e. FASN and SREBP-1c, remains unaltered. The 5-LO inhibition restores hepatic microsomal triglyceride transfer protein, MTP, activity in parallel with a stimulation of hepatic VLDL-TG and ApoB secretion in obese mice, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Mus musculus P48999 C57BL/6J mice
-
1.13.11.34 Mus musculus C57/BL6J P48999 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 hepatocyte
-
 Mus musculus
-
1.13.11.34 liver increased enzyme activity in obese mice compared to twild-type mice, overview Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus leukotriene A4 + H2O
-
 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus C57/BL6J leukotriene A4 + H2O
-
 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus C57/BL6J leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2
-
 Mus musculus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 arachidonic acid + O2
-
 Mus musculus C57/BL6J (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 additional information 5-LO inhibition in obese mice downregulates genes involved in hepatic fatty acid uptake, i.e. L-FABP and FAT/CD36, and normalizes PPARalpha and acyl-CoA oxidase expression, whereas the expression of lipogenic genes, i.e. FASN and SREBP-1c, remains unaltered. The 5-LO inhibition restores hepatic microsomal triglyceride transfer protein, MTP, activity in parallel with a stimulation of hepatic VLDL-TG and ApoB secretion in obese mice, overview Mus musculus ?
-
 ?
1.13.11.34 additional information 5-LO inhibition in obese mice downregulates genes involved in hepatic fatty acid uptake, i.e. L-FABP and FAT/CD36, and normalizes PPARalpha and acyl-CoA oxidase expression, whereas the expression of lipogenic genes, i.e. FASN and SREBP-1c, remains unaltered. The 5-LO inhibition restores hepatic microsomal triglyceride transfer protein, MTP, activity in parallel with a stimulation of hepatic VLDL-TG and ApoB secretion in obese mice, overview Mus musculus C57/BL6J ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-LO
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.34 37
-
 assay at Mus musculus