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Literature summary extracted from

  • Yee, J.K.; Mao, C.S.; Hummel, H.S.; Lim, S.; Sugano, S.; Rehan, V.K.; Xiao, G.; Lee, W.N.
    Compartmentalization of stearoyl-CoA desaturase enzyme-1 activity in HepG2 cells (2008), J. Lipid Res., 49, 2124-2134.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 CGX0168
-
 Homo sapiens
1.14.19.1 CGX0290
-
 Homo sapiens
1.14.19.1 trans-10,cis-12 conjugated linoleic acid inhibits stearate desaturation only, not that of palmitate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 additional information Homo sapiens role of SCD1 in fatty acid metabolism in HepG2 cells, the desaturation systems in Hep-G2 cells are strongly compartmentalized, effects of SCD1 inhibition on fatty acid composition in HepG2 cells occur through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms, overview ?
-
 ?
1.14.19.1 palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+ Homo sapiens a key step in triglyceride synthesis in the fatty acid metabolic network palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Homo sapiens a key step in triglyceride synthesis in the fatty acid metabolic network oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 Hep-G2 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.19.1 additional information
-
 fatty acid compositions in presence and absence of inhibitors Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 additional information role of SCD1 in fatty acid metabolism in HepG2 cells, the desaturation systems in Hep-G2 cells are strongly compartmentalized, effects of SCD1 inhibition on fatty acid composition in HepG2 cells occur through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms, overview Homo sapiens ?
-
 ?
1.14.19.1 palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+ a key step in triglyceride synthesis in the fatty acid metabolic network Homo sapiens palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ a key step in triglyceride synthesis in the fatty acid metabolic network Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
-
 Homo sapiens
1.14.19.1 stearoyl-CoA desaturase enzyme-1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 ferrocytochrome b5
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.19.1 0.00058
-
 cell assay Homo sapiens CGX0290
1.14.19.1 0.00152
-
 biochemical assay Homo sapiens CGX0290
1.14.19.1 0.00172
-
 biochemical assay Homo sapiens CGX0168
1.14.19.1 0.00187
-
 cell assay Homo sapiens CGX0168