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Literature summary extracted from

  • Schweiger, D.; Fuerstenberger, G.; Krieg, P.
    Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways (2007), J. Lipid Res., 48, 553-564.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.40 expression and establishment of a doxycycline-inducible Tet-On gene expression system in the premalignant mouse keratinocyte cell line 308 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.40 additional information doxycycline-inducible expression in keratinocytes 308 leads to an inhibition of cell growth that is associated with an inhibition of DNA synthesis, as shown by a reduction of 5-bromo-2-deoxy-uridine incorporation up to 46%, doxycycline-induced keratinocytes show increased levels of reactive oxygen species. The antioxidant N-acetyl-L-cysteine and a specific inhibitor of p38 mitogen-activated protein kinase, but not of extracellular signal-regulated kinase 1/2 or c-Jun N-terminal kinase/stress-activated kinases, completely abolish the LOX-induced growth inhibition Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.40 baicalein
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.40 arachidonate + O2 Mus musculus
-
 (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
-
 ?
1.13.11.40 additional information Mus musculus the inducible expression of 8-lipoxygenase inhibits cell growth, 15-LOX-2 and 8-LOX, although displaying different positional specificity, use common signaling pathways to induce growth inhibition in premalignant epithelial cells, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.40 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.40 arachidonate + O2
-
 Mus musculus (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
-
 ?
1.13.11.40 additional information the inducible expression of 8-lipoxygenase inhibits cell growth, 15-LOX-2 and 8-LOX, although displaying different positional specificity, use common signaling pathways to induce growth inhibition in premalignant epithelial cells, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.40 8-lipoxygenase
-
 Mus musculus
1.13.11.40 8-LOX
-
 Mus musculus
1.13.11.40 More the enzyme belongs to the LOX family Mus musculus